American Chemical Society
ol006390b_si_001.pdf (597.33 kB)

Intramolecular 4 + 3 Cycloadditions. Aspects of Stereocontrol in the Synthesis of Cyclooctanoids. A Synthesis of (+)-Dactylol

Download (597.33 kB)
journal contribution
posted on 2000-08-05, 00:00 authored by Michael Harmata, Paitoon Rashatasakhon
The judicious placement of stereocenters on precursors for 4 + 3 cycloaddition reactions can lead to high levels of stereocontrol in the 4 + 3 cycloaddition process of cyclopentenyl cations and tethered butadienes. This concept was successfully tested in the context of a synthesis of (+)-dactylol.