American Chemical Society
ol3c02794_si_001.pdf (9.7 MB)

Interrupted Furan–Yne Cyclization: Access to Unsaturated Dicarbonyl Compounds and Their Subsequent Transformation into Functionalized Pyridazines

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journal contribution
posted on 2023-10-20, 15:35 authored by Yury A. Vasev, Ekaterina R. Nasibullina, Anton S. Makarov, Maxim G. Uchuskin
The key carbenoid intermediate of transition-metal-catalyzed furan–yne cyclization in Hashmi phenol synthesis could be efficiently intercepted with water under the developed reaction conditions in order to provide access to functionalized unsaturated dicarbonyl compounds that might serve as convenient precursors for the straightforward synthesis of annulated pyridazines.