am5b08493_si_001.pdf (2.53 MB)
Download fileInterfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity
journal contribution
posted on 2015-10-28, 00:00 authored by Guocheng Wang, Xiaobing Zhao, Marco Möller, Sergio E. MoyaWe report the interfacial reaction-driven
formation of micro/nanostructured strontium carbonate (SrCO3) biomorphs with subcellular topographical features on strontium
zinc silicate (Sr2ZnSi2O7) biomedical
coatings and explore their potential use in bone tissue engineering.
The resulting SrCO3 crystals build a well-integrated scaffold
surface that not only prevents burst release of ions from the coating
but also presents nanotopographical features similar to cellular filopodia.
The surface with biomorphic crystals enhances osteoblast adhesion,
upregulates the alkaline phosphatase activity, and increases collagen
production, highlighting the potential of the silica carbonate biomorphs
for tissue regeneration.
History
Usage metrics
Categories
Keywords
osteoblast adhesionSr 2ZnSifilopodiasurfacestrontium zinc silicatetissue regenerationphosphatase activitynanotopographical featuresInterfacialFormationburst releaseBiological ActivityWe reportbiomorphic crystalsincreases collagen productionsilica carbonate biomorphsSrCO 3 crystalsupregulateformationSilica Carbonate Biomorphssubcellular topographical featurescoatingSubcellular Topographical Featuresbone tissue engineeringscaffold