am5b08493_si_001.pdf (2.53 MB)
Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity
journal contributionposted on 2015-10-28, 00:00 authored by Guocheng Wang, Xiaobing Zhao, Marco Möller, Sergio E. Moya
We report the interfacial reaction-driven formation of micro/nanostructured strontium carbonate (SrCO3) biomorphs with subcellular topographical features on strontium zinc silicate (Sr2ZnSi2O7) biomedical coatings and explore their potential use in bone tissue engineering. The resulting SrCO3 crystals build a well-integrated scaffold surface that not only prevents burst release of ions from the coating but also presents nanotopographical features similar to cellular filopodia. The surface with biomorphic crystals enhances osteoblast adhesion, upregulates the alkaline phosphatase activity, and increases collagen production, highlighting the potential of the silica carbonate biomorphs for tissue regeneration.
osteoblast adhesionSr 2ZnSifilopodiasurfacestrontium zinc silicatetissue regenerationphosphatase activitynanotopographical featuresInterfacialFormationburst releaseBiological ActivityWe reportbiomorphic crystalsincreases collagen productionsilica carbonate biomorphsSrCO 3 crystalsupregulateformationSilica Carbonate Biomorphssubcellular topographical featurescoatingSubcellular Topographical Featuresbone tissue engineeringscaffold