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Download fileInteractions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II)
journal contribution
posted on 04.08.2014, 00:00 authored by Luigi Messori, Tiziano Marzo, Elena Michelucci, Irene Russo Krauss, Carmen Navarro-Ranninger, Adoracion G. Quiroga, Antonello MerlinoThe adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II),
[t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg
white lysozyme and bovine pancreatic ribonuclease, were independently
characterized by X-ray crystallography and electrospray ionization
mass spectrometry. In these adducts, the PtII center, upon
chloride release, coordinates either to histidine or aspartic acid
residues while both alkylamino ligands remain bound to the metal.
Comparison with the cisplatin derivatives of the same proteins highlights
for [t-PtCl2(dma)(ma)] a kind of biomolecular metalation
remarkably different from that of cisplatin.
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adductcoordinatecisplatin derivativesbiomolecular metalationchloride releasecrystallographykindCrystal Structurespancreatic ribonucleaseCompoundInteractionSpectraProteinsPtII centeraspartic acid residueshistidinei.eAnticancerProtein Adductsalkylamino ligandslysozymetranelectrospray ionization mass spectrometrymodel proteins