posted on 2005-06-13, 00:00authored bySimone Schillo, Vojislav Pejović, Christian Hunzinger, Torsten Hansen, Slobodan Poznanović, Jörg Kriegsmann, Werner J. Schmidt, André Schrattenholz
Glutamate is the major excitatory neurotransmitter in the mammalian brain and is related to memory
by calcium-conducting receptors. Neuregulins have emerged as long-term modulating molecules of
synaptic signaling by glutamate receptors, playing a role in some cognition/memory-related disorders
and moreover being part of transient functional microdomains, called lipid rafts. Here we characterize
one specific isoform of neuregulin as a central biomarker for glutamate-related signaling, integrating
results from in vitro and in vivo models by a differential functional and proteomic approach.
Keywords: neuregulin • learning • memory • radial maze • glutamate • NMDA receptor • hippocampal neurons •
differential proteomics • calcium transient