American Chemical Society
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Integrative Proteomics:  Functional and Molecular Characterization of a Particular Glutamate-Related Neuregulin Isoform

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journal contribution
posted on 2005-06-13, 00:00 authored by Simone Schillo, Vojislav Pejović, Christian Hunzinger, Torsten Hansen, Slobodan Poznanović, Jörg Kriegsmann, Werner J. Schmidt, André Schrattenholz
Glutamate is the major excitatory neurotransmitter in the mammalian brain and is related to memory by calcium-conducting receptors. Neuregulins have emerged as long-term modulating molecules of synaptic signaling by glutamate receptors, playing a role in some cognition/memory-related disorders and moreover being part of transient functional microdomains, called lipid rafts. Here we characterize one specific isoform of neuregulin as a central biomarker for glutamate-related signaling, integrating results from in vitro and in vivo models by a differential functional and proteomic approach. Keywords: neuregulin • learning • memory • radial maze • glutamate • NMDA receptor • hippocampal neurons • differential proteomics • calcium transient