jo061644d_si_001.pdf (4.16 MB)
Insights into the General and Efficient Cross McMurry Reactions between Ketones
journal contribution
posted on 2006-12-22, 00:00 authored by Xin-Fang Duan, Jing Zeng, Jia-Wei Lü, Zhan-Bin ZhangThe selective cross McMurry couplings of diaryl or aryl
ketones with various substituted ketones were achieved in
53−94% isolated yields. It is believed that the strong affinity
of the substituents to the low-valent titanium surface plays
an important role in regards to moderating selectivity.
Through the introduction of such substituents followed by
their removal post McMurry coupling, structurally similar
ketones can be effectively cross-coupled.