jo061644d_si_001.pdf (4.16 MB)
Insights into the General and Efficient Cross McMurry Reactions between Ketones
journal contributionposted on 2006-12-22, 00:00 authored by Xin-Fang Duan, Jing Zeng, Jia-Wei Lü, Zhan-Bin Zhang
The selective cross McMurry couplings of diaryl or aryl ketones with various substituted ketones were achieved in 53−94% isolated yields. It is believed that the strong affinity of the substituents to the low-valent titanium surface plays an important role in regards to moderating selectivity. Through the introduction of such substituents followed by their removal post McMurry coupling, structurally similar ketones can be effectively cross-coupled.