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Inhibition of Cytokine Production by Hymenialdisine Derivatives

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journal contribution
posted on 01.07.2004, 00:00 by Vasudha Sharma, Theresa A. Lansdell, Guangyi Jin, Jetze J. Tepe
We describe herein the synthesis and biological activity of two indoloazepines that are structurally related to the marine sponge metabolite hymenialdisine. The natural product hymenialdisine was found to be a potent inhibitor of interleukin-2 (IC50 = 2.4 μM) and tumor necrosis factor α (IC50 = 1.4 μM) production. One of the hymenialdisine derived indoloazepines was found to also inhibit interleukin-2 (IC50 = 3.5 μM) and tumor necrosis factor α (IC50 = 8.2 μM) production.