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Inexpensive Radical Methylation and Related Alkylations of Heteroarenes

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journal contribution
posted on 13.02.2018, 21:30 by Qi Huang, Samir Z. Zard
A simple method for the introduction of a methyl and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-methyl pyrrolidone in a microwave oven.