am8b11980_si_001.pdf (966.85 kB)

Indole Derivative-Capped Gold Nanoparticles as an Effective Bactericide in Vivo

Download (966.85 kB)
journal contribution
posted on 07.08.2018, 00:00 by Xiaohui Zhao, Yuexiao Jia, Juanjuan Li, Ruihua Dong, Jiangjiang Zhang, Chuanxin Ma, Hui Wang, Yukui Rui, Xingyu Jiang
We synthesize indole derivative-capped gold nanoparticles (Au_IDs) via a straightforward route to fight multidrug-resistant (MDR) bacteria. When gold nanoparticles are modified with two indole derivatives, tryptophan and 5-aminoindole, they exhibit excellent antibacterial activities against both laboratory antibiotic-sensitive and MDR bacteria. Au_IDs possess remarkable bactericidal activities against MDR bacteria killing 99.9% of MDR Escherichia coli and polymyxin-resistant Klebsiella pneumoniae after 0.5 h of incubation, which are superior to clinical antibiotics including polymyxin B and cefotaxime. By evaluating the potential of Au_IDs in wound cure, Au_IDs show outstanding capability in MDR bacterial wound infection. Our findings provide new candidates for the development of bactericides and the fabrication of wound dressings for treating MDR infection.

History

Exports