Indium Promotes Direct Sulfonamidation of Unactivated Alcohols

An improved protocol has been developed for the direct sulfonamidation of unactivated alkyl alcohols using In(OTf)₃ as a Lewis acid catalyst. Although the established methods using Lewis or Brønsted acids have been well-studied for the direct functionalization of alcohols, their substrate scope mainly focuses on the π-activated alcohols. In this reaction, unactivated aliphatic alcohols were evaluated and afforded the desired sulfonamide products with good to excellent yields.