American Chemical Society
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Indium Promotes Direct Sulfonamidation of Unactivated Alcohols

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journal contribution
posted on 2024-04-11, 16:09 authored by Yaoyao Ban, Yuhan Liu, Shuwei Zhang, Xiaodong Jia, Pan Gao, Yu Yuan
An improved protocol has been developed for the direct sulfonamidation of unactivated alkyl alcohols using In(OTf)3 as a Lewis acid catalyst. Although the established methods using Lewis or Brønsted acids have been well-studied for the direct functionalization of alcohols, their substrate scope mainly focuses on the π-activated alcohols. In this reaction, unactivated aliphatic alcohols were evaluated and afforded the desired sulfonamide products with good to excellent yields.