Inclusion Complexation and Solubilization of Paclitaxel by Bridged Bis(β-cyclodextrin)s Containing a Tetraethylenepentaamino Spacer
journal contributionposted on 23.09.2003, 00:00 by Yu Liu, Guo-Song Chen, Li, Heng-Yi Zhang, Dong-Xu Cao, Ying-Jin Yuan
A novel water-soluble paclitaxel complex has been prepared by inclusion complexation with bridged bis(β-cyclodextrin)s and characterized by means of 1H NMR, SEM, powder X-ray diffraction patterns, TG-DTA, DSC, FT-IR, and 2D NOESY. The cyclodextrins were able to solubilize paclitaxel to levels as high as 2 mg/mL. Furthermore, the cytotoxicity of the novel complexes was assessed using a K562 leukemia cell line which indicated that drug concentrations of 10 pg/mL elicited an inhibitory effect.