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Download fileInclusion Complexation and Solubilization of Paclitaxel by Bridged Bis(β-cyclodextrin)s Containing a Tetraethylenepentaamino Spacer
journal contribution
posted on 2003-09-23, 00:00 authored by Yu Liu, Guo-Song Chen, Li, Heng-Yi Zhang, Dong-Xu Cao, Ying-Jin YuanA novel water-soluble paclitaxel complex has been
prepared by inclusion complexation with bridged bis(β-cyclodextrin)s and characterized by means of 1H NMR, SEM,
powder X-ray diffraction patterns, TG-DTA, DSC, FT-IR, and
2D NOESY. The cyclodextrins were able to solubilize paclitaxel
to levels as high as 2 mg/mL. Furthermore, the cytotoxicity of
the novel complexes was assessed using a K562 leukemia cell
line which indicated that drug concentrations of 10 pg/mL
elicited an inhibitory effect.