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In Situ-Generated Chiral Co(I)-Catalyst for Asymmetric [2+2+2] Cycloadditions of Triynes

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journal contribution
posted on 04.04.2016, 00:00 by Phillip Jungk, Fabian Fischer, Marko Hapke
The development of an in situ catalytic system based on cobalt­(II)-salts, chiral P,N-ligands, and a reductant for the intramolecular asymmetric cyclization of triynes is described. This system represents the first chiral in situ-generated Co­(I)-catalyst system for asymmetric [2+2+2] cycloadditions. The system consists only of commercially available components and leads to high yields and selectivities for the [2+2+2] cycloaddition of triynes in up to 16 examples.