posted on 2019-02-11, 11:48authored byXiaofang Lei, Yuanyuan Wang, Erkang Fan, Zhihua Sun
Activation
of disulfides with N-halogen succinimide
in the presence of TEMPO allows insertion reaction by an isocyanide,
the product of which can further accept a wide range of nucleophiles
for the generation of isothioureas and related molecular moieties.
This new procedure overcomes previous methods that accept essentially
only aryl amines as the third nucleophilic component. The diverse
nucleophiles usable in our new protocol make this approach a general
method for de novo synthesis of many S-containing heterocycles.