In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe₂SiH with Carboxylic Acids:  Direct Chemo- and Regioselective Friedel−Crafts Acylation of Aromatic Ethers

Chemoselective dehydrogenative interaction of ClMe₂SiH with a carboxylic acid group in the presence of InX₃ is reported. ¹³C NMR investigation revealed the formation of PhCOOSi(Cl)Me₂ as the major transient intermediate. Chemo- and regioselective Friedel−Crafts acylation of aromatic ethers directly from carboxylic acids was established.