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In(III)-Mediated Chemoselective Dehydrogenative Interaction of ClMe2SiH with Carboxylic Acids:  Direct Chemo- and Regioselective Friedel−Crafts Acylation of Aromatic Ethers

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journal contribution
posted on 2007-02-01, 00:00 authored by Srinivasarao Arulananda Babu, Makoto Yasuda, Akio Baba
Chemoselective dehydrogenative interaction of ClMe2SiH with a carboxylic acid group in the presence of InX3 is reported. 13C NMR investigation revealed the formation of PhCOOSi(Cl)Me2 as the major transient intermediate. Chemo- and regioselective Friedel−Crafts acylation of aromatic ethers directly from carboxylic acids was established.