posted on 2020-03-13, 16:08authored byJiafeng Li, Qian Chen, Qin Zhang, Tiantang Fan, Li Gong, Wuyou Ye, Zhongyong Fan, Lu Cao
Exploiting
the solid-state drawing (SSD) process toward polymer materials for
medical implant devices is of significance to simultaneously improve
the mechanical property and biocompatibility. Herein, for the first
time, the bionic implants with a microvalley surface of oriented long
chain branching PLA (b-PLA) was fabricated by a feasible SSD process.
The as-obtained b-PLAs could not only show a high tensile strength
(278.1 MPa) and modulus (4.32 GPa) but also bear a superior protein
adsorption as high as 622 ng/cm2. Such exceptional mechanical
properties and biocompatibility could be ascribed to the SSD process-induced
highly orientation degree and the morphology of parallel grooves within
ridges structures, resulting in the greatly enhanced crystallinity
and surface hydrophobicity as well as a biocompatible vascular endothelial
microstructure for cell to adhesion and growth and thus an improved
proliferation, differentiation, and activity of osteoblasts with spindle-shaped
and spread morphology on surface of the b-PLAs. These findings may
pave the way for designing the novel biomaterials for vascular stent
or tissue engineering devices by the SSD process.