Improvement of Obesity Phenotype by Chinese Sweet Leaf Tea (Rubus suavissimus) Components in High-Fat Diet-Induced Obese Rats
journal contributionposted on 12.01.2011, 00:00 by Gar Yee Koh, Kathleen McCutcheon, Fang Zhang, Dong Liu, Carrie A. Cartwright, Roy Martin, Peiying Yang, Zhijun Liu
Drinking an herbal tea to lose weight is a well-liked concept. This study was designed to examine the possible improvement of obesity phenotype by a new tea represented by its purified components, gallic acid, ellagic acid, and rubusoside (GER). Male obese-prone SD rats were given low-fat diet, high-fat diet, or high-fat diet plus GER at the dose of 0.22 g/kg of body weight for 9 weeks. GER significantly reduced body weight gain by 22% compared to the high-fat diet control group with 48% less abdominal fat gain. Food intake was not affected. Blood glucose was lowered in the GER-treated group, whereas serum triglycerides and cholesterol were significantly reduced by 50%. This improved obesity phenotype may be associated with the attenuated expression of vascular endothelial growth factor in preadipocyte 3T3-L1 cells. Although other underlying, possibly multiple, mechanisms behind the improved phenotype are largely unknown, the observed improvement of multiple obesity-related parameters by the new tea warrants further investigations.