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Improved Chemical Syntheses of 1- and 5-Deazariboflavin

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journal contribution
posted on 02.04.2004, 00:00 by Erin E. Carlson, Laura L. Kiessling
The cofactor flavin adenine dinucleotide (FAD) is required for the catalytic activity of a large class of enzymes known as flavoenzymes. Because flavin cofactors participate in catalysis via a number of different mechanisms, isoalloxazine analogues are valuable for mechanistic studies. We report improved chemical syntheses for the preparation of the two key analogues, 5-deazariboflavin and 1-deazariboflavin.