ao8b01478_si_001.pdf (869.35 kB)
Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
journal contribution
posted on 2018-09-20, 18:03 authored by Candy
S. Hwang, Lauren C. Smith, Yoshihiro Natori, Beverly Ellis, Bin Zhou, Kim D. JandaFentanyl
and its derivatives have become pervasive contaminants
in the U.S. heroin supply. Previously, we reported a proof-of-concept
vaccine designed to combat against heroin contaminated with fentanyl.
Herein, we optimized the admixture vaccine and found that it surpassed
the individual vaccines in every antinociceptive test, including a
10% fentanyl to heroin formulation. It is anticipated that other co-occurring
drug abuse disorders may also be examined with admixture vaccines.