Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides
journal contributionposted on 23.10.2009, 00:00 by Ui Joung Youn, Ye Seul Lee, Hana Jeong, Jun Lee, Joo-Won Nam, Yoo Jin Lee, Eun Sook Hwang, Je-Hyun Lee, Dongho Lee, Sam Sik Kang, Eun-Kyoung Seo
Three new phenolic compounds, (E)-4′-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4−10). The structures of the new compounds (1−3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.