American Chemical Society
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Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides

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journal contribution
posted on 2009-10-23, 00:00 authored by Ui Joung Youn, Ye Seul Lee, Hana Jeong, Jun Lee, Joo-Won Nam, Yoo Jin Lee, Eun Sook Hwang, Je-Hyun Lee, Dongho Lee, Sam Sik Kang, Eun-Kyoung Seo
Three new phenolic compounds, (E)-4′-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (410). The structures of the new compounds (13) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.