I2‑Catalyzed C–O Bond Formation
and Dehydrogenation: Facile Synthesis of Oxazolines and Oxazoles Controlled by Bases

Gao, Wen-Chao; Hu, Fei; Huo, Yu-Ming; Chang, Hong-Hong; Li, Xing; Wei, Wen-Long

doi:10.1021/acs.orglett.5b01933.s001

ol5b01933_si_001.pdf (6.19 MB)

I₂‑Catalyzed C–O Bond Formation and Dehydrogenation: Facile Synthesis of Oxazolines and Oxazoles Controlled by Bases

journal contribution

posted on 2015-08-07, 00:00 authored by Wen-Chao Gao, Fei Hu, Yu-Ming Huo, Hong-Hong Chang, Xing Li, Wen-Long Wei

A general method for the synthesis of oxazolines and oxazoles was developed through I₂-catalyzed C–O bond formation and dehydrogenation with the same oxidant, TBHP. By simply tuning reaction bases, either oxazolines or oxazoles were selectively produced from β-acylamino ketones.