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Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii

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journal contribution
posted on 18.03.2020, 11:03 by Jian-Fa Zong, Zhu Hu, Ying-Ying Shao, Qing Shi, Meng-Meng Zhang, Yu-Bo Zhou, Jia Li, Ai-Jun Hou
Hyperprins A (1) and B (2), two polyprenylated acylphloroglucinol related meroterpenoids with undescribed carbon skeletons, were isolated from Hypericum przewalskii. Compound 1 possesses a new 6/6/6/6/5/5 hexacyclic system with an unprecedented tetracyclo­[,8.08,12]­hexadecane motif. Compound 2 features a unique 6/8/6/6 tetracyclic scaffold. Their structures were determined by spectroscopic data, chemical method, and X-ray crystallography. Compound 1 showed antiproliferation activity against the MV-4-11 cell line, and the p-bromobenzoate derivative of 2 displayed PTP1B inhibition.