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Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity
journal contribution
posted on 2009-02-09, 00:00 authored by Semra Colak, Christopher F. Nelson, Klaus Nüsslein, Gregory N. TewHere we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).
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moietieMICAmphiphilic PolynorborneneHCconcentrationcopolymerization1.15zwitterionicbiocompatible groupspostpolymerization techniquescopolymersAntibacterial ActivityHeremodificationpolydispersity indicespolynorbornenepolyethylene glycolincorporationHydrophilic Modificationsratio3 kDa1.08amphiphilicHemolytic
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