American Chemical Society
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Hydrogenation of Hindered Ketones Catalyzed by a Silica-Supported Compact Phosphine−Rh System

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journal contribution
posted on 2008-10-16, 00:00 authored by Soichiro Kawamorita, Go Hamasaka, Hirohisa Ohmiya, Kenji Hara, Atsushi Fukuoka, Masaya Sawamura
A heterogeneous mono(phosphine)−Rh catalyst system silica-SMAP−Rh(OMe)(cod), where silica-SMAP stands for a caged, compact trialkylphosphine (SMAP) supported on silica gel, showed broad applicability toward the hydrogenation of hindered ketones. Doubly α-branched ketones such as diisopropyl ketone was hydrogenated under nearly atmospheric conditions. Di-tert-butyl ketone could be hydrogenated under more forcing conditions.