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Hydrogen Sulfide-Responsive Self-Assembled Nanogel

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journal contribution
posted on 28.08.2020, 20:31 authored by Peng-Hao Hsu, Riku Kawasaki, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Atsushi Ikeda, Adah Almutairi
Hydrogen sulfide (H2S) is a signaling molecule whose overexpression is identified in various cancers. Despite the flourishing research of H2S-responsive nanomaterials, the development of H2S-responsive nanogels (NGs) has not been attempted yet. Here we report, for the first time, H2S-responsive NG, which was formulated from H2S-responsive cholesterol-modified dextran (SC-Dex) through self-assembly. H2S induces the dissociation of cholesterols from the dextran backbone of SC-Dex via reduction of aryl azide and the subsequent 1,4-rearrangement. In the presence of H2S, SC-Dex NGs show swelling behavior and controlled release of encapsulated protein. This NG might show potential applications as a H2S-responsive drug delivery system.