American Chemical Society
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Hydrogen Bond Catalyzed Direct Reductive Amination of Ketones

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journal contribution
posted on 2006-02-16, 00:00 authored by Dirk Menche, Jorma Hassfeld, Jun Li, Gerd Menche, Antje Ritter, Sven Rudolph
A novel, biomimetic concept for the direct reductive amination of ketones is described that relies on selective imine activation by hydrogen bond formation. The mild, acid- and metal-free process requires only catalytic amounts of thiourea as hydrogen bond donor and utilizes the Hantzsch ester for transfer hydrogenation. The method allows the efficient synthesis of structurally diverse amines.