ol8b04100_si_001.pdf (3.67 MB)
Hydride Transfer Involved Redox-Neutral Cascade Cyclizations for Construction of Spirocyclic Bisoxindoles Featuring a [3,4]-Fused Oxindole Moiety
journal contribution
posted on 2019-02-05, 20:21 authored by Shuai-Shuai Li, Shuai Zhu, Chunqi Chen, Kang Duan, Qing Liu, Jian XiaoThe hydride transfer involved redox-neutral
cascade cyclization
has been developed to construct the spirocyclic bisoxindoles featuring
a [3,4]-fused oxindole moiety from rationally designed C4-amine-substituted
isatins, affording the diverse tricyclic [3,4]-fused oxindoles with
three consecutive chiral centers in good yields and excellent diastereoselectivities
(>20:1).