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Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64

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journal contribution
posted on 06.07.2012, 00:00 by Qian Che, Tianjiao Zhu, Xin Qi, Attila Mándi, Tibor Kurtán, Xiaomei Mo, Jing Li, Qianqun Gu, Dehai Li
Indotertine A (1), a hybrid isoprenoid with a condensed pentacyclic skeleton, together with two related hybrid isoprenoids, drimentines F (2) and G (3), were isolated from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. Their structures including absolute configurations were elucidated by spectroscopic methods, X-ray single crystal diffraction analysis, and TDDFT ECD calculations. Drimentines G (3) showed strong cytotoxicity against human cancer cells lines with IC50's down to 1.01 μM, while 1 and 2 showed no significant activity.