American Chemical Society
ol501826a_si_001.pdf (1.43 MB)

Hyalachelins A–C, Unusual Siderophores Isolated from the Terrestrial Myxobacterium Hyalangium minutum

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journal contribution
posted on 2014-08-15, 00:00 authored by Suvd Nadmid, Alberto Plaza, Gianluigi Lauro, Ronald Garcia, Giuseppe Bifulco, Rolf Müller
Three new siderophores, termed hyalachelins A–C (13), were isolated from the terrestrial myxobacterium Hyalangium minutum. Their structures were determined by 2D NMR and HR-MS/MS experiments, and their stereochemical configuration was established by a combination of NMR data, quantum mechanical calculations, and circular dichroism experiments. Hyalachelins are unusual catecholate-type siderophores that bear a 3,7,8-trihydroxy-1-oxo-1,2,3,4-tetra­hydro­isoquinoline-3-carbox­ylic acid. Their iron chelating activities were evaluated in a CAS assay showing EC50 values of ∼30 μM.