posted on 2021-10-19, 16:39authored byJiro Nakatani, Tatsuhiro Nozoe
A new process for the synthesis of
2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl
(TFMB) comprising three steps has been industrially developed. The
first step is the homocoupling of the Grignard reagent derived from
1-chloro-2-(trifluoromethyl)benzene with iron chloride(III) in the
presence of an oxidizing agent to afford 2,2′-bis(trifluoromethyl)biphenyl.
The second step is the nitration of this biphenyl to 2,2′-bis(trifluoromethyl)-4,4′-dinitrobiphenyl,
and the third step is the reduction of this dinitrobiphenyl using
hydrogen over Pd/C to afford TFMB. This process has been demonstrated
on an industrial scale.