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Homoallyllic Nitrone Isomerization: Convenient Enantioselective Synthesis of Homoallylic Nitrones and Homoallylic Hydroxylamines

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journal contribution
posted on 03.07.2008, 00:00 by Hin-Soon Cheng, Ai-Hua Seow, Teck-Peng Loh
An α-regioselective synthesis of homoallylic nitrones from aldehydes is reported on the basis of [3,3]-sigmatropic rearrangement. The products are obtained in up to 99% enantioselectivity and up to 80% yield under environmentally benign and mild reaction conditions.