American Chemical Society
ol100490y_si_001.pdf (239.79 kB)

Highly Substituted 2,3-Dihydroisoxazoles by Et3N-Catalyzed Tandem Reaction of Electron-Deficient 1,3-Conjugated Enynes with Hydroxylamines

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journal contribution
posted on 2010-04-16, 00:00 authored by Xiuzhao Yu, Bo Du, Kai Wang, Junliang Zhang
An Et3N-catalyzed tandem reaction of electron-deficient 1,3-conjugated enynes with hydroxylamines was developed which provided rapid, metal-free, and regioselective access to highly substituted multifunctionalized 2,3-dihydroisoxazoles under mild conditions. The reactions of 3-(2-arylethynyl)-4H-chromen-4-ones with hydroxylamines afford β-amino enones under the same reaction conditions.