posted on 2018-01-17, 00:00authored byQingzhou Liu, Yihang Liu, Fanqi Wu, Xuan Cao, Zhen Li, Mervat Alharbi, Ahmad N. Abbas, Moh R. Amer, Chongwu Zhou
Nanoribbon-
and nanowire-based field-effect transistor (FET) biosensors
have stimulated a lot of interest. However, most FET biosensors were
achieved by using bulky Ag/AgCl electrodes or metal wire gates, which
have prevented the biosensors from becoming truly wearable. Here,
we demonstrate highly sensitive and conformal In2O3 nanoribbon FET biosensors with a fully integrated on-chip
gold side gate, which have been laminated onto various surfaces, such
as artificial arms and watches, and have enabled glucose detection
in various body fluids, such as sweat and saliva. The shadow-mask-fabricated
devices show good electrical performance with gate voltage applied
using a gold side gate electrode and through an aqueous electrolyte.
The resulting transistors show mobilities of ∼22 cm2 V–1 s–1 in 0.1× phosphate-buffered
saline, a high on–off ratio (105), and good mechanical
robustness. With the electrodes functionalized with glucose oxidase,
chitosan, and single-walled carbon nanotubes, the glucose sensors
show a very wide detection range spanning at least 5 orders of magnitude
and a detection limit down to 10 nM. Therefore, our high-performance
In2O3 nanoribbon sensing platform has great
potential to work as indispensable components for wearable healthcare
electronics.