Highly Selective Cascade Couplings for the Syntheses of Functionalized Piperidinones and Bispidines
journal contributionposted on 05.07.2007, 00:00 by Feng Xu, Edward Corley, Jerry A. Murry, David M. Tschaen
Efficient cascade couplings to synthesize functionalized piperidinones 1 and bispidines 2 and 3 have been developed. Simple modifications to the reaction conditions allow for the highly controlled and selective formation of each compound. In addition, the cis isomer of 1 can be selectively obtained under acidic conditions, while the preparation of the corresponding trans isomer can also be readily realized through a base-catalyzed, dynamic crystallization-driven process.