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Highly Regioselective C–N Bond Formation through C–H Azolation of Indoles Promoted by Iodine in Aqueous Media

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journal contribution
posted on 07.12.2012, 00:00 by Wen-Bin Wu, Jing-Mei Huang
An efficient and metal-free method for the direct C–N coupling of indoles with azoles to produce 2-(azol-1-yl)indoles in aqueous solution has been developed. This reaction proceeded highly regioselectively to provide a variety of indole derivatives with good to excellent yields.