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Highly Regio- and Stereoselective Synthesis of Polysubstituted Cyclopropane Compounds via the Pd(0)-Catalyzed Coupling−Cyclization Reaction of 2-(2‘,3‘-Allenyl)malonates with Organic Halides

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journal contribution
posted on 17.09.2004, 00:00 by Shengming Ma, Ning Jiao, Qing Yang, Zilong Zheng
A new method for highly regio- and stereoselective synthesis of polysubstituted cyclopropane compounds via the Pd(0)-catalyzed coupling−cyclization reaction of 2-(2‘,3‘-allenyl)malonates with organic halides is described. In these reactions, the starting materials are easily available and the operation is convenient. The ratios of trans-isomer/cis-vinylic cyclopropanes are up to 98:2.