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Highly Regio- and Stereoselective Synthesis of Boron-Substituted Enynes via Copper-Catalyzed Borylation of Conjugated Diynes

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journal contribution
posted on 20.02.2015, 00:00 by DingXi Li, Yeong Eun Kim, Jaesook Yun
A mild copper-catalyzed regio- and stereoselective monoborylation of conjugated diynes with bis­(pinacolato)­diboron that affords enynyl­boronates is reported. The reaction is efficient for different types of conjugated diynes including unsymmetrical diynes and produces enynylboron compounds with high and complementary regioselectivity compared with classical hydrometalation reactions. In particular, the reactions of internal conjugated diynes with a silyl substitution produced highly functionalized enynes with high regio- and stereoselectivity, which can be used in further transformations.