American Chemical Society
ol202555v_si_002.pdf (1.09 MB)

Highly Enantioselective and Regioselective Substitution of Morita–Baylis–Hillman Carbonates with Nitroalkanes

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journal contribution
posted on 2011-11-18, 00:00 authored by Guo-Ying Chen, Fangrui Zhong, Yixin Lu
A highly enantioselective and regioselective substitution reaction of the Morita–Baylis–Hillman (MBH) carbonates with nitroalkanes catalyzed by a quinidine-derived tertiary amine–thiourea catalyst has been developed. The described method, which is different from most organocatalytic allylic substitutions of the MBH adducts to date, represents a novel approach to regioselectively functionalize the MBH adducts.