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Highly Enantioselective and Organocatalytic α-Amination of 2-Oxindoles

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journal contribution
posted on 03.09.2009, 00:00 by Liang Cheng, Li Liu, Dong Wang, Yong-Jun Chen
An effective method for the asymmetric synthesis of 3-amino-2-oxindoles was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of N-unprotected 2-oxindoles with azodicarboxylate catalyzed by commercial biscinchona alkaloids in good to excellent yields with high enantioselectivities.