Highly Enantioselective Synthesis of Tetrahydro-β-Carbolines and
Tetrahydro-γ-Carbolines Via Pd-Catalyzed Intramolecular Allylic Alkylation

Bandini, Marco; Melloni, Alfonso; Piccinelli, Fabio; Sinisi, Riccardo; Tommasi, Simona; Umani-Ronchi, Achille

doi:10.1021/ja054109o.s001

ja054109o_si_001.pdf (283.95 kB)

Highly Enantioselective Synthesis of Tetrahydro-β-Carbolines and Tetrahydro-γ-Carbolines Via Pd-Catalyzed Intramolecular Allylic Alkylation

journal contribution

posted on 2006-02-08, 00:00 authored by Marco Bandini, Alfonso Melloni, Fabio Piccinelli, Riccardo Sinisi, Simona Tommasi, Achille Umani-Ronchi

A novel Pd-catalyzed intramolecular allylic alkylation of indoles allows THBCs and THGCs to be effectively synthesized in high yields and excellent enantiomeric excesses (ee up to 97%).

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ee Allylic enantiomeric excesses intramolecular THGC Alkylation indole Tetrahydro allylic alkylation THBC Via yield Intramolecular Enantioselective Synthesis

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