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Highly Enantioselective Synthesis of Multifunctionalized Dihydrofurans by Copper-Catalyzed Asymmetric [4 + 1] Cycloadditions of α‑Benzylidene-β-ketoester with Diazo Compound

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posted on 19.02.2016, 13:11 by Jiao-Long Zhou, Li-Jia Wang, Hao Xu, Xiu-Li Sun, Yong Tang
Highly efficient synthesis of chiral tetrasubstituted 2,3-dihydrofuran derivatives has been realized by Cu-catalyzed asymmetric [4 + 1] cycloadditions of α-benzylidene-β-ketoester with a diazo compound. Following this methodology, a series of optically active multifunctionalized dihydrofurans were prepared in high yield with up to 96% ee and 99/1 dr.

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