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Highly Enantioselective Catalytic Carbon Dioxide Incorporation Reaction:  Nickel-Catalyzed Asymmetric Carboxylative Cyclization of Bis-1,3-dienes

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journal contribution
posted on 19.05.2004, 00:00 by Masanori Takimoto, Yoichi Nakamura, Kaoru Kimura, Miwako Mori
A method for nickel-catalyzed asymmetric carbon dioxide (CO2) incorporation via carbon−carbon bond formation was developed. In the presence of a catalytic amount of Ni(acac)2 and MeO-MOP, various bis-1,3-dienes reacted with CO2 (1 atm) and a diorganozinc reagent (Me2Zn or Ph2Zn) to afford cyclic carboxylic acids in good yields (71−100%) and with high enantioselectivities (90−96% ee).