ja049506y_si_001.pdf (276.73 kB)
Highly Enantioselective Catalytic Carbon Dioxide Incorporation Reaction: Nickel-Catalyzed Asymmetric Carboxylative Cyclization of Bis-1,3-dienes
journal contributionposted on 2004-05-19, 00:00 authored by Masanori Takimoto, Yoichi Nakamura, Kaoru Kimura, Miwako Mori
A method for nickel-catalyzed asymmetric carbon dioxide (CO2) incorporation via carbon−carbon bond formation was developed. In the presence of a catalytic amount of Ni(acac)2 and MeO-MOP, various bis-1,3-dienes reacted with CO2 (1 atm) and a diorganozinc reagent (Me2Zn or Ph2Zn) to afford cyclic carboxylic acids in good yields (71−100%) and with high enantioselectivities (90−96% ee).