Highly Enantioselective Catalytic Carbon Dioxide Incorporation Reaction:  Nickel-Catalyzed Asymmetric Carboxylative Cyclization of Bis-1,3-dienes

A method for nickel-catalyzed asymmetric carbon dioxide (CO₂) incorporation via carbon−carbon bond formation was developed. In the presence of a catalytic amount of Ni(acac)₂ and MeO-MOP, various bis-1,3-dienes reacted with CO₂ (1 atm) and a diorganozinc reagent (Me₂Zn or Ph₂Zn) to afford cyclic carboxylic acids in good yields (71−100%) and with high enantioselectivities (90−96% ee).