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Highly Enantioselective Addition of N‑2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride

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journal contribution
posted on 27.01.2021, 17:54 by Jie Chen, Dong-yu Zhu, Xue-jing Zhang, Ming Yan
An enantioselective Michael addition between N-2,2,2-trifluoroethylisatin ketimines and ethylene sulfonyl fluoride has been disclosed. This method provides a facile strategy to access a range of structurally diverse isatin-derived α-(trifluoromethyl)­imine derivatives with excellent yields and enantioselectivities. The intriguing combination of α-(trifluoromethyl)­amine and sulfonyl fluoride groups leads to the valuable candidates for the drug discovery.