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Highly Efficient and Selective Electrochemical Synthesis of Substituted Benzothiophenes and Benzofurans in Microcontinuous Flow

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journal contribution
posted on 27.08.2020, 16:06 by Dong Zhang, Jinlin Cai, Zheng Fang, Jinze Du, Xinxin Lin, Chengkou Liu, Wei He, Zhao Yang, Kai Guo
A green and practical method for the synthesis of C-3 halogenated benzothiophenes and benzofurans from 2-alkynylthioanisoles or 2-alkynylanisoles and potassium halide was developed under transition-metal- and oxidant-free conditions, employing an assembled electrochemistry continuous-flow system. The carbon and platinum plates were used as the anode and cathode, respectively; KI or KBr not only served as a halogen source but also as an electrolyte. Moderate to good yields of C-3 halogenated benzothiophenes and benzofuran derivatives were obtained under constant current. Notably, the halogen could also be restored at the cathode to obtain C-3 dehalogenated benzothiophenes and benzofurans in high selectivity by adjusting the current and flow rate of the continuous-flow system. Moreover, this reaction could be easily scaled up with good efficiency in the continuous-flow system, which presents major advantages over reactions in a traditional batch.

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