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Highly Efficient Enantiospecific Synthesis of Imidazoline-Containing Amino Acids Using Bis(triphenyl)oxodiphosphonium Trifluoromethanesulfonate

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journal contribution
posted on 13.05.2004, 00:00 by Shu-Li You, Jeffery W. Kelly
A highly efficient enantiospecific synthesis of imidazoline-based amino acids is reported from dipeptides composed of a C-terminal β-amino-α-amino acid residue using bis(triphenyl) oxodiphosphonium trifluoromethanesulfonate. These imidazolines were easily converted to imidazoles and incorporated into macrolactam analogues of bistratamide H without loss of stereochemical integrity.