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Highly Efficient Chemoselective Synthesis of Polysubstituted Pyrroles via Isocyanide-Based Multicomponent Domino Reaction

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journal contribution
posted on 16.08.2013, 00:00 by Xiang Wang, Xiao-Ping Xu, Shun-Yi Wang, Weiqun Zhou, Shun-Jun Ji
A multicomponent domino reaction for the chemoselective, catalyst-free synthesis of polysubstituted pyrroles from readily available isocyanides, primary or secondary amines, and gem-diactivated olefins has been developed. Structurally diverse pyrroles were obtained in moderate to good yields under mild conditions.

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