Highly Efficient Catalytic System for C–H Activation: A Practical Approach to Angiotensin II Receptor Blockers

An efficient protocol for C–H activation provided a greener and sustainable approach to angiotensin II receptor blockers (ARBs). The use of PPh₃ in a specific ratio to inexpensive RuCl₃·xH₂O resulted in a discovery of an unprecedentedly efficient catalytic system for C–H activation which permitted a practical access to ARBs. The process is atom economical and much greener compared to the previous methods which need stoichiometric amount of hazardous organometallics.