Highly Efficient Catalytic System for C–H Activation: A Practical Approach to Angiotensin II Receptor Blockers
journal contributionposted on 03.06.2011, 00:00 by Masahiko Seki
An efficient protocol for C–H activation provided a greener and sustainable approach to angiotensin II receptor blockers (ARBs). The use of PPh3 in a specific ratio to inexpensive RuCl3·xH2O resulted in a discovery of an unprecedentedly efficient catalytic system for C–H activation which permitted a practical access to ARBs. The process is atom economical and much greener compared to the previous methods which need stoichiometric amount of hazardous organometallics.