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Highly Efficient Asymmetric Synthesis of 3-Indolyl(hydroxy)acetates via Friedel−Crafts Alkylation of Indoles

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journal contribution
posted on 04.09.2009, 00:00 by Yonghai Hui, Qi Zhang, Jun Jiang, Lili Lin, Xiaohua Liu, Xiaoming Feng
An efficient enantioselective Friedel−Crafts alkylation of indoles to ethyl glyoxylate catalyzed by chiral N,N′-dioxide−Sc(III) complex was developed. The corresponding 3-indolyl(hydroxy)acetates compounds were afforded in good yields with high enantioselectivities (up to 95% ee).

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