ol063097o_si_001.pdf (3.1 MB)
Download file

Highly Diastereoselective Preparation of (E)-Alkenylsilanes Bearing an α-Chiral Center

Download (3.1 MB)
journal contribution
posted on 15.03.2007, 00:00 by Sylvie Perrone, Paul Knochel
The copper(I)-mediated anti-SN2‘ allylic substitution allows a highly stereoselective preparation of alkenylsilanes bearing a chiral center in the α-position with high transfer of chirality. These alkenylsilanes were converted into α,β-unsaturated ketones or into the corresponding boronic esters without loss of the chiral information.